Indications and Usage
Typhim Vi vaccine is indicated for active immunization against typhoid fever for persons two years of age or older. Immunization with Typhim Vi vaccine should occur at least two weeks prior to expected exposure to S typhi.
Dosage and Administration
For intramuscular (i.m.) injection.
- Typhim Vi vaccine is indicated for persons two years of age and older.
- The immunizing dose for adults and children is a single injection of 0.5 mL. The dose for adults is given intramuscularly in the deltoid, and the dose for children is given IM either in the deltoid or the vastus lateralis. The vaccine should not be injected into the gluteal area or areas where there may be a nerve trunk.
- A reimmunizing dose is 0.5 mL. Reimmunization consisting of a single dose for US travelers every two years under conditions of repeated or continued exposure to the S typhi organism is recommended at this time.
- For children below the age of 2 years, safety and effectiveness have not been established.
Dosage Forms and Strengths
Syringe, without needle, 0.5 mL
- Hypersensitivity to any component of the vaccine.
- Postpone in acute severe febrile illness.
Warnings and Precaution
- Appropriate medical treatment and supervision should always be readily available in cases of a rare anaphylactic reaction following administration of the vaccine.
- Special care should be taken to ensure that Typhim Vi vaccine is not injected into a blood vessel.
- The adverse reactions to the vaccine are minor and transient local reactions. Local reactions such as injection site pain, erythema and induration almost always resolved within 48 hours of vaccination. Elevated oral temperature, above 38°C (100.4°F), was observed in approximately 1% of vaccinees in all studies. No serious or life-threatening systemic events were reported in these clinical trials.
- Most subjects reported pain and/or tenderness (pain upon direct pressure). Local adverse experiences were generally limited to the first 48 hours.
- Reactions at the injection site, including soreness, redness and swelling
Use in Specific Populations
- For pregnant and lactating, Typhim Vi should only be used when there is high risk of infection.